Vassilia Orfanou, PhD, Post Doc
Writes for the Headline Diplomat eMagazine
Researchers at Yale University have developed a method to deliver mRNA directly to the lungs. They created polymer nanoparticles that can carry the mRNA and be inhaled through the air. This new delivery approach has the potential to revolutionize vaccination by allowing people in remote areas or those afraid of needles to receive vaccines. However, there are concerns about the ethical implications of using this method without an individuals’ knowledge or consent, and an undeniable history of the U.S. government of carrying out secret bioweapon experiments.
The technique was tested on mice and was successful in intranasal vaccinations, which could pave the way for potential human trials. This breakthrough was reported by Mercola and initially reported in LifeSiteNews.
Scientists have developed an aerosolized mRNA COVID-19 vaccine, receiving accolades from the scientific community for its effectiveness in vaccinating the population. Nonetheless, there are apprehensions regarding the potential misuse of this vaccine for nefarious purposes, including clandestine bioenhancements.
Yale scientists conducted research on mice and developed polymer nanoparticles that encapsulated mRNA, making it breathable so that it would reach the lungs, Courtney Malo, an editor for Science Translational Medicine which published the study, “explained“.
Suberi et al. demonstrated that mRNA delivery to the lungs could be attained through encapsulating the desired mRNAs in poly(amine-co-ester) polyplexes [nanoparticles]. When delivered by this method, the mRNAs were proficiently translated into proteins in the lungs of mice, with low signs of toxicity. This platform was then used for an intranasal SARS-CoV-2 vaccine, which induced strong immune responses and protected the mice against a subsequent viral attack. These discoveries point to the possibility of this delivery system being employed for vaccine development and other purposes.
Mark Saltzman, a cellular and molecular physiologist, headed the team that demonstrated that an inhalable mRNA vaccine could protect against SARS-CoV-2, offering a potential new path for using mRNA therapeutics for gene replacement therapy and other treatments in the respiratory system.
This research study demonstrated that two intranasal doses of nanoparticles containing mRNA COVID-19 vaccines were effective in mice. Historically, mRNA therapies that were intended to target the lungs had a low rate of delivery into the necessary cells to create the encoded protein, otherwise known as poor transfection efficiency.
Saltzman and his team were able to address the difficulty through the utilization of a nanoparticle composed of poly(amine-co-ester) polyplexes or PACE, which was described as biocompatible and customizable in a statement from Yale University. In a previous research, Saltzman had attempted a “prime and spike” approach to administer COVID-19 vaccines, involving the injection of mRNA shots into a muscle accompanied by the application of spike proteins to the nose.
Saltzman harbors great expectations for the airborne delivery method, potentially going beyond vaccines, and it seemed that the injection component may be superfluous.
The new report is devoid of intramuscular injection. We administered two doses, a prime and a boost, through the nose that yielded a highly successful immune response. Additionally, it was noted that mRNA can be administered in a variety of different ways, making it not only viable for vaccines, but also for gene replacement therapy for diseases such as cystic fibrosis and gene editing. It was demonstrated it in a vaccine setting, but this introduces possibilities to explore other types of interventions.
Vaccination could be revolutionized by the introduction of air vax
According to Saltzman, this innovative system of delivering the vaccine could revolutionize the way people are getting vaccinated. It would be particularly beneficial for those living in remote locations or those with a fear of needles. Moreover, it can also facilitate quick dispersal of the vaccine across a wide population.
Rather than having to inject each person one-by-one, the vaccine can be released into the air, eliminating the need for individual consent or even the public’s knowledge. This would be faster and more efficient than the traditional method.
To combat a virus, ViAqua developed an oral “nanovaccine” to treat shrimp, which are too small and numerous to be injected individually. Shai Ufaz, the CEO of ViAqua, mentioned that giving treatments orally is regarded as the most desirable way to progress the health of aquaculture because not only is vaccinating each shrimp impossible, but it also reduces the cost of managing diseases while achieving better results…
The Yale researchers are aiming for an intranasal mRNA product, with the goal of providing the most exposed individuals with the least amount of cost and effort. The Yale study, here, states that this is the desired outcome.
An inhalable platform for messenger RNA (mRNA) therapeutics could allow for a less intrusive and lung targeted approach to a variety of pulmonary diseases. The utilization of mRNA therapeutics for this purpose, however, has been hindered by the low transfection rates and the possibility of vehicle-induced pathology.
To combat this, we studied the potential of biodegradable poly(amine-co-ester) polyplexes (nanoparticles) with end-group modifications and polyethylene glycol to deliver therapeutic mRNAs to the lung. Results showed that these polyplexes had high transfection rates in all areas of the lung, but particularly in epithelial and antigen-presenting cells.
We then used this technology to develop a mucosal vaccine for severe acute respiratory syndrome coronavirus 2, which lead to the induction of a significant cellular and humoral adaptive immunity and successfully protected susceptible mice from a lethal viral challenge. Our findings indicate that PACE polyplexes have a great potential for the therapeutic delivery of mRNA to the lungs.
The U.S. government has a record of having released bioweapons in the past
An unsettling image is revealed when the facts are analysed. According to The Epoch Times, we have witnessed the U.S. government taking drastic steps to urge and facilitate the public to receive the COVID-19 vaccine. A recent survey has revealed that most Americans have no intention to receive the new COVID vaccine.
Now, scientists have designed a aerosolized mRNA vaccine that could be used to rapidly inoculate the people without their knowledge or permission.
Are there any indications that the government or another entity has intentions to secretly employ an airborne vaccine on citizens? The answer is no. However, there is a history of the U.S. Navy engaging in secret bioweapon experiments on American people. For instance, in 1950, Serratia marcescens bacteria was sprayed into the atmosphere around San Francisco over the course of six days.
Called “Operation Sea Spray,” the mission was meant to estimate how vulnerable the city was to a bioweapon assault. Serratia marcescens colors whatever it touches a vivid red, making it simple to follow. It disseminated through the city, with citizens taking in the organisms from the air. The U.S. military initially believed Serratia marcescens would not have an adverse effect on humans, however an episode happened, with some getting urinary tract infections in response.
Smithsonian Magazine reported that there had been at least one casualty and some people speculated that the release of the bioweapon had a lasting effect on the area’s microbial ecology. Moreover, the U.S. government carried out numerous experiments in the country over the next two decades, making the air vax experiment on an unsuspecting public not an isolated occurrence, but a rather disturbing one.
Recent research in the field of bioethics encourages a hidden and mandatory form of bio-augmentation.
In the academic journal Bioethics, Parker Crutchfield of Western Michigan University’s Homer Stryker M.D. School of Medicine has offered his endorsement for the compulsory and clandestine implementation of bioenhancements. This endorsement pertains to moral bioenhancements, which are seen as using biomedical techniques to promote moral growth.
Bioenhancements, such as vaccines and genetic engineering, can be explored as potential treatments. Additionally, Crutchfield attests that these methods can be included in the realm of bioenhancements.
To avoid potential damage, it is essential to morally improve the population through bioenhancement. Moral bioenhancement involves altering a person’s moral attitude, motivation, or disposition via biological means.
Although the technology for this kind of intervention is still quite primitive, possible interventions include adding pharmaceuticals that induce empathy or selflessness into water supplies, or manipulating a person’s emotions or will to affect their moral conduct.
A new study has discovered a definite correlation between the introduction of a COVID-19 vaccine and the maximum amount of all-cause mortality.
Crutchfield contends that moral bio-enhancements should not only be compulsory but also covert; he does not think that the merely compulsory approach is sufficient. This idea is explained further here.
I extend this argument by proposing that if moral bio-enhancement is mandatory, it should be done in a clandestine manner rather than in the open. That is to suggest that it is more ethical to administer compulsory moral bio-enhancement without the individuals being aware that they are getting the enhancement.
He proposed that “values such as liberty, utility, equality and autonomy” are better served with a covert program of releasing drugs and bio-enhancements to the public rather than an overt one. Therefore, there is scholarly support for this idea. Additionally, the development of an airborne mRNA vaccine and the government’s past of conducting trials on the general population paints an alarming image of what’s to come.
Challenges remain concerning mRNA COVID injections
Risks to health are still present with mRNA COVID-19 vaccinations, no matter how the vaccine is administered. An announcement was recently made by the U.S. Centers for Disease Control and Prevention and the Food and Drug Administration which stated that those 65 and older who had the Pfizer bivalent booster may have an increased risk of stroke.
An exploration of how the US government employed data and language to pressure Americans to get the COVID-19 vaccine may be seen here.
A substantial investigation from Israel has indicated that Pfizer’s COVID-19 mRNA vaccine is linked with a threefold augmented danger of myocarditis which could occur in between 1 and 5 events out of 100,000 people. Other heightened probabilities were also discovered after the COVID jab, counting lymphadenopathy (inflamed lymph nodes), appendicitis and herpes zoster infection.
At least 16,183 people have reported developing tinnitus after receiving a COVID-19 vaccination, according to the CDC’s Vaccine Adverse Event Reporting System (VAERS) database. However, since only between 1-10 percent of adverse reactions are ever reported to VAERS, it is likely that the real number of individuals affected is much higher.
The necessity of obtaining informed consent before any medical procedure, such as vaccinations, is due to the potential risks associated. However, the arrival of mRNA vaccinations delivered through the air has made it more likely that this consent could be taken away.
Conclusion
In conclusion, the development of an inhalable mRNA delivery system by Yale University researchers has undoubtedly opened new possibilities in the field of vaccination and therapeutics. The potential for an airborne mRNA vaccine, termed “air vax,” could revolutionize the way people receive vaccines, especially benefiting those in remote areas or with needle phobias. However, as with any groundbreaking technology, ethical concerns arise.
The prospect of administering vaccines without individual consent or knowledge raises ethical red flags, given historical instances of secret bioweapon experiments by the U.S. government. The need for transparency and respect for individual autonomy must be paramount in adopting such innovative approaches.
The success of the intranasal mRNA vaccine in mice, as demonstrated by the Yale study, suggests promising avenues for human trials. The absence of intramuscular injections and the potential for broader applications beyond vaccinations, such as gene replacement therapy, adds to the significance of this research.
Yet, caution is warranted. The historical context of bioweapon experiments and recent discussions on covert bio-enhancements underscore the importance of ethical considerations in advancing medical technologies. The idea of mandatory and clandestine bio-enhancements, as proposed in bioethics, prompts a critical examination of the balance between public health interests and individual rights.
Moreover, the challenges and potential risks associated with mRNA COVID-19 vaccinations, regardless of delivery method, emphasize the ongoing need for informed consent. Recent reports of adverse reactions underscore the importance of transparency and thorough risk communication.
In embracing technological advancements, it is essential to strike a balance between medical progress and ethical considerations. The “air vax” innovation holds promise, but its implementation must be guided by principles that respect individual autonomy, informed consent, and democratic values. The future of medicine should not compromise the fundamental rights and well-being of the people it aims to serve.
Call to action
As we navigate the possibilities of inhalable mRNA vaccines, it’s crucial to emphasize ethical considerations. Any advancement of medical technologies should promote transparency, informed consent, and respect for individual autonomy. Let’s ensure that the future of medicine upholds our fundamental rights and well-being. Your involvement matters. We call for ethical innovations today.
Featured Photo: Nikita Skripnik: https://www.pexels.com/el-gr/photo/11883239/
